General overview

This is one of our 2 "partner sites". We've been working closely together for more than 5 years time, & in reality we work as one team, sharing each project's daily tasks. The team is composed of 15 chemists, including 2PhD's(1 with post-doc experience). Project scope typically includes both designing & developing/optimizing 3-10 steps of chemistry towards a unique molecule which is intended to be further scaled down the line. This R&D site also has a full range of capabilities, including both gram scale R&D as well as gram to multi-kilo scale production. In addition to the typical stand-up hoods, we also have large scale walk-in hoods allowing for the ability to develop & scale new chemistry quickly & efficiently on-site. Special capabilities include low temperature, on-site hydrogenation & silica purification area. Our chemists have access to the full range of analytical & literature searching tools, in order to ensure that the best process is designed & efficiently developed. All personnel are thoroughly trained on the concepts of western project confidentiality expectations, & employment requirements strictly re-enforcing these same expectations.

Project scope

We work both under price per kilo contracts & in FTE arrangements. Heterocyclic chemistry, especially pyridine-related, is a well-known team expertise. Our typical project involves 2-10 chemistry steps, & scale is anywhere from gram to kilo of final product. Early large scale intermediates can be produced outside in one of our production facilities (Lianyungang, Shangyu, Yiwu), & final process steps performed in the above mentioned kilo suites, as necessary. When & if needed, we can continue to scale-up the chemistry within our Lianyungang commercial production facility.

Typical Reaction Expertise

Analytical Capabilities

• NMR (300mHz, 500mHz)
• Mass Spectrometer
• LC-MS
• GC-MS
• FT-IR
• UV-Vis
• GC's
• HPLC's
• AAS
• ICP
• Elemental analysis
• Partical size analysis
• X-ray analysis
• Karl Fischer
• Melt point
• LOD
• Residue on ignition
• ee% testing
• Optical Rotation

Raw material sourcing advantage description: Click on this link

In-fact this is one of our most significant industry advantages. We have been sourcing raw materials in china & qualifying both suppliers & products, for more than 15 year's time. Our raw material sourcing database now holds records on more than 15,000 different molecules, & more than 5,000 different chinese suppliers. As part of our daily sourcing activities, our Nanjing team is required to "qualify suppliers", & place all related information into the database for future reference. All materials are tested, vendor performance monitored, & results assessed & placed into the database. The result of all these efforts gives us an ability to find local raw materials very quickly, while preventing wasted time in working with unreliable high risk suppliers. This has proven to greatly reduce our R&D & production leadtimes, while giving our teams a greater range of materials & suppliers to choose from. On special request from our close customer-partners, we also perform a customized sourcing & supplier selection service to fit their individual needs for purchasing china materials. This includes material lot to lot analysis work, packaging service, factory visits/pre-audits, & full export management including customs clearance & door to door delivery.